The LB3P: Low Back Pain Research Study is a Mechanistic Research Center funded through a U19 award from the National Institutes of Health's HEAL (Helping to End Addiction Long-Term) Initiative, a strategic effort to combat the opioid epidemic in the United States. The LB3P Center is a member of the BACPAC (Back Pain Consortium), 13 research sites, which will work together to develop an integrated model of chronic low back pain to guide the future study and treatment of this condition. This study is conducted by researchers at the University of Pittsburgh Departments of Physical Therapy, Physical Medicine & Rehabilitation, Psychiatry, and Orthopaedic Surgery.
The LB3P Center is an innovative, multidisciplinary collaboration of investigators at UPMC and the University of Pittsburgh. The Center will collect data from three key contributing domains of chronic low back pain: biological, biomechanical, and behavioral. The data will be analyzed to perform in-depth phenotyping of patients with chronic low back pain with the goal of characterizing patients and directing targeted treatments. This is a novel, integrated biopsychosocial approach to combat such a complex and multi-dimensional condition.
UPMC Press Release on the grant.
Over the next four years, the LB3P hopes to recruit 1,000 study participants to help with the collection of biological, biomechanical, and behavioral data. Participants will be asked to answer questionnaires, perform functional assessments, and submit to collecting biological samples. Testing and collection will take place at the Physical Therapy - Clinical and Translational Research Center at the University of Pittsburgh. The PT-CTRC is a state-of-the-art facility that will serve as the hub for study participation. Interested persons must be over age 18, experiencing ongoing low back pain for more than 3 months in the last 6 months. Individuals chosen to participate will be compensated for their time.
- Principal Investigators
Gwendolyn Sowa, MD, PhD, Department of Physical Medicine & Rehabilitation
Nam Vo, PhD, Department of Orthopaedic Surgery
- Core Leadership
Sara Piva, PhD, PT, Department of Physical Therapy
Anthony Delitto, PhD, PT, FAPTA, School of Health and Rehabilitation Sciences
Carol Greco, PhD, Department of Psychiatry
Michael Schneider, DC, PhD, Department of Physical Therapy
Kevin Bell, PhD, Department of Bioengineering
William Anderst, PhD, Department of Orthopaedic Surgery
Charity Patterson, PhD, MSPH, Department of Physical Therapy
Gina McKernan, PhD, Department of Physical Medicine & Rehabilitation
- Study Staff
Selena Crawford, Project Manager
Jessa Darwin, Communications Manager
Marit E. Johnson, PhD, Biomechanics Core Project Manager
Corey Flynn, Clinical Core Research Project Coordinator
Lisa Bemis, Biodynamics Lab Manager
Interested participants must be 18 years of age and older, and have experienced low back pain for more than 3 months in the last 6 months. Visit our patient portal for more information about the study and to see if you qualify for participation.
Poster presentation at Orthopaedic Research Society's 2022 meeting, "Asymmetrical Lumbar Intervertebral Motion in Chronic Low Back Pain" by Dr. Marit Johnson